Breast/ovarian cancer, familial (BRCA1/BRCA2 gene)

Clinical Information

MATERIAL & VOLUME
EDTA blood, 2x 2-5ml


NOTES
-Declaration of consent is required (Form)
-Attach family medical history


CLINICAL INFORMATION
Each year, about 6000 women in Switzerland are diagnosed with breast cancer, and 600 women with ovarian cancer. About 24% of these familial tumor diseases can be attributed to pathogenic variants in the high-risk genes BRCA1 and BRCA2. Male BRCA mutation carriers may also be at increased risk for breast cancer and other tumor diseases. In addition to the two high-penetrance BRCA genes, mutations in other genes are also known to be predisposing to breast and/or ovarian cancer.


INDICATIONS FOR TESTING
-Especially in cases of inherited predisposition to breast cancer and possibly other cancers based on the personal and family medical history
-Early-onset of illness
-Presymptomatic genetic testing for known familial BRCA variant



RELATED TEST PROFILES, ESTIMATED TURNAROUND TIMES AND COSTS
Profile Test Est. TAT Est. Costs
9475 complete BRCA1 and BRCA2 gene test (incl. gene dose alterations): 4 - 8 weeks CHF 3700 - 4000
8552 complete BRCA1 only gene test (incl. gene dose alterations): 4 - 8 weeks CHF 3000
8553 complete BRCA2 only gene test (incl. gene dose alterations): 4 - 8 weeks CHF 3000
01417 Gene dosage analysis of known familial BRCA1 deletion: 2 - 4 weeks CHF 450
01420 Gene dosage analysis of known familial BRCA2 deletion: 2 - 4 weeks CHF 450
8556 Sequencing of known familial BRCA1/2 variant: 2 - 4 weeks CHF 300


POSITION / PRICE
Positions: Insurance covered
Price: Pos.Nr.: TP/CHF:
DNA-Extraction 6001.03 61
NGS 6241.60 2900
MLPA 6241.55* 350
Sanger-Sequencing 6241.56 215
58* 215
* This position can vary depending on the number of genes to be analysed and the variants found.


METHOD
NGS – Sequencing of the complete coding sequence of the BRCA1 and/or BRCA2 genes (+/- 10 base pairs)
MLPA – Determination of gene dosage alterations (deletions/duplications) in the genes BRCA1- and/or BRCA2
Sanger sequencing – Targeted identification of known familial BRCA1or BRCA2 pathogenic variants by sequencing one exon


TESTING LABORATORY
labor team w ag
Blumeneggstrasse 55
9403 Goldach

Associated profiles
NO. Description Material
9475 Breast Cancer 2x EDTA Blood
8552 BRCA1 gene 2x EDTA Blood
8553 BRCA2 gene 2x EDTA Blood
01417 BRCA1 MLPA analysis 2x EDTA Blood
01420 BRCA2 MLPA analysis 2x EDTA Blood
8556 Breast Cancer familial mutation (BRCA1/BRCA2) 2x EDTA Blood
Index
Synonyms
Product names
Analyses groups
etc.
  • Breast cancer
  • ovarian cancer
Contact
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