616 - Paroxetine

Material & Volume
  • Serum, 1ml
Reference values
Age Sex Pregnant Range Unit
All No 20-65 therapeutic range
>120 toxic
μg/l
Clinical Information

Paroxetin is an anti-depressive member of the ‘SSR’ Group of selective serotonin re-uptake inhibitors, and is administered for the treatment of depression, post-traumatic stress disruptions, anxiety, panic- and compulsive –disorders. The effective mechanism of the agent is based upon the inhibition of the serotonin transporter ‘SERT’, and thus ultimately the re-uptake of serotonin in the nerve cell. This causes the serotonin concentration to be enhanced in the synaptic cleft, which has the effect of triggering anti-depressive effects. Apart from the foregoing, paroxetin is a strong ‘CYP2D6’ inhibitor, but this produces more possible side effects for the patient as with other similar anti-depressive agents. These include vomiting, headache, vertigo, tremor and sexual dysfunction.

Type of drug: Antidepressant
Metabolism: CYP2D6, CYP3A4, P-gp(ABCB1)
Half life t½: 12-44h
Steady State: 1-2 weeks
TDM: useful
Additional informations: Inhibition of CYP2D6

More information
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Product names
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etc.
  • Deroxat®
Position / Price
Position: 1065.00
Price: CHF 126.00
+ Processing fee:
(per order and per day)
CHF 21.60
Method
  • LC-MS
Executing laboratory
labor team w ag
Blumeneggstrasse 55
9403 Goldach
Execution time
1 day
Contact
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