726 - Vancomycin
- Serum, 1ml
Age | Range | Unit |
---|---|---|
All | 15-25 Dose every 6h 10-20 Dose every 12h 15-20 Staphylococcus aureus |
mg/l |
Vancomycin is a glycopeptide-antibiotic, which is administered in case of infections with gram-positive bacteria and employed against multi-resistant staphylococci as a reserve antibiotic. The active ingredient is gained from special actino-bacteria (Amycolatopsis orientalis) and works via the inhibition of the bacterial cell-wall synthesis; i.e. vancomycin is deposited at the free C-terminal end of the peptide side chain of the peptidoglycan gram-positive bacteria in the cell wall. This causes a disruption of the cross-linking in the cell wall and it thus becomes unstable, whereby the bacteria are caused to burst. Vancomycin however has no effect on gram-negative bacteria. Possible undesirable side effects can beneutropenia, over sensitiveness, ototoxicity and kidney functional disruptions.
Type of drug: Antibiotic
Metabolism: Not metabolised
Half life t½: 3-8h
Steady State: 1-2 days
TDM: recommended
Additional informations: A concentration above 10 mg/l should be achieved in any case in order to avoid resistence. A TDM is recommended for patients with modified pharmacokinetics: this applies to patients with overweight problems, kidney dysfunction or dysplasia.
- Vancocin®
Position: | 1060.00 |
Price: | CHF 103.50 |
+ Processing fee: (per order and per day) |
CHF 21.60 |
- LC-MS
Blumeneggstrasse 55
9403 Goldach