7728 - Edoxaban (anti-factor Xa)
- Citrate plasma 1:10
LMW Heparin (low molecular-weight Heparin), unfractionated Heparin and the ‘new orally administered anticoagulants’ (NOACs, e.g. Fondaparinux, Rivaroxaban, etc.) have the effect of the preferred ‘Xa’ inhibitor factor because of their structure and molecular weight distribution. The dosage of such anticoagulants has to be adjusted to weight; laboratory checks are normally not necessary. Clinical indications for determining the ‘anti-factor Xa activity’ are: kidney insufficiency, pregnancy, long-term therapies, extreme bleeding- or thrombosis –hazard, or extreme over- or underweight, and in newborn babies and small children.
N.B.: Please always contact us by phone (under 071 844 4545), to ensure immediate sample collection; blood samples should preferably be taken in the morning . Blood samples should be taken 2 (-4) hours after the medication has been administered. For evaluation purposes, we need the data of the administered medication: please select the appropriate Profile Number accordingly.
When edoxaban 60 mg is administered, peak concentrations (2 hours after ingestion) of 302 ng / ml and trough levels of continuous therapy of 36.1 ng / ml are expected.