83150 - Transtubular potassium gradient

Material & Volume
  • Serum, 1ml
  • Urine, 10ml
Clinical Information


TTKG Interpretation of the data

8 - 9 Normal

> 10 Normal aldosterone effect
< 5-7 Extrarenal cause of hyperkalemia, impaired potassium secretion in aldosterone deficiency/resistance

After administration of 0.05 mg 9-a-fludrocortisone (artificial mineralocorticoid)
Initial < 5-7, then > 10 Hypoaldosteronism probable
Initial < 5-7, no change K+-sparing diuretics (spironolactone, triamterene, amiloride), tubular aldosterone resistance (interst. nephritis, obstruction, pseudohypoaldosteronism type I, sickle cell disease), drugs (trimethoprim, pentamidine), increased distal K+ reabsorption (pseudohypoaldosteronism type II, obstruction).

< 2 extrarenal loss
> 2 renal loss

1) West ML et al. New clinical approach to evaluate disorders of potassium excretion. Miner Electrolyte Metab 1986; 12: 234+B18
2) Ethier JH et al. The transtubular potassium concentration in patients with hypokalemia and hyperkalemia. Am J Kidney Dis 1990; 15: 309
3) Rose BD, Post TW. Clinical physiology of acid-based and electrolyte disorders, 5th ed, McGraw-Hill, New York, 2001; pp. 900-901+B92

Related analyses
Description Material
Osmolality Serum
Potassium Serum
Osmolality Urine
Potassium Urine
Transtubular potassium gradient Calculated
Position / Price
Position: Mandatory provision
Price: CHF 45.60
+ Processing fee:
(per order and per day)
CHF 24.00
Executing laboratory
labor team w ag
Blumeneggstrasse 55
9403 Goldach
Execution time
1 day
During opening-hours:
Outside opening-hours: