0551 - Hereditary spherocytosis (SH),EMA

Material & Volume
  • EDTA Blood, 1ml
Reference values
Age Sex Pregnant Range Unit
All No <25 %
Clinical Information

Hereditary spherocytosis (SH) is one of the most common forms of congenital anemia in Northern Europe.
Due to various defects in the erythrocyte membrane, which promote the spherical shape of the erythrocytes and reduce their plasticity, increased degradation in the spleen leads to hemolytic anemia.
The clinical features of classic HS are hemolysis with anemia, reticulocytosis, splenomegaly, jaundice, spherocytosis, increased erythrocyte osmotic fragility and relative family history.

The examination is carried out by flow cytometry (FACS):
The binding of the green fluorescent eosin-5-maleimide dye (EMA) to the erythrocyte membrane band 3 is examined. In most forms of hereditary spherocytosis, EMA binding to the destabilized erythrocyte membrane is reduced by 25-30% (sensitivity 90-95%, specificity 95-99%).

Index
Synonyms
Product names
Analyses groups
etc.
  • EMA
Position / Price
Position: 1649.00
Price: CHF 13.20
+ Processing fee:
(per order and per day)
CHF 24.00
Executing laboratory
labor team w ag
Blumeneggstrasse 55
9403 Goldach
Execution time
1 day
Contact
During opening-hours:
Outside opening-hours: